Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.33 |
| ▸ | BRS3 | P32247 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531741 | 0.91 | AGTR1 (0.33) | AGTR1AGTR2BRS3AKT1CACNA1G | |
| SCHEMBL9533032 | 0.90 | AGTR1 (0.33) | AGTR1AGTR2BRS3CACNA1GCACNA1H | |
| SCHEMBL9705208 | 0.88 | AGTR1 (0.33) | AGTR1AGTR2BRS3CACNA1GCACNA1H | |
| SCHEMBL9532052 | 0.88 | BRS3 (0.38) | AGTR1AGTR2BRS3 | |
| SCHEMBL9530491 | 0.81 | AGTR1 (0.32) | AGTR1AGTR2 | |
| SCHEMBL9534439 | 0.81 | AGTR1 (0.32) | AGTR1AGTR2 | |
| SCHEMBL9531633 | 0.80 | AGTR1 (0.32) | AGTR1AGTR2 | |
| SCHEMBL9531866 | 0.80 | HSD11B1 (0.33) | AGTR1AGTR2 | |
| SCHEMBL9531333 | 0.80 | AGTR1 (0.31) | AGTR1AGTR2 | |
| SCHEMBL9530075 | 0.80 | AGTR1 (0.31) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555331-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS. | SEARLE & CO (US) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992007834-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |