Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 5/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532628 | 0.94 | PDE3B (0.52) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL9529954 | 0.77 | PDE3B (0.58) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL9532636 | 0.71 | HTR2A (0.33) | NPC1CYP11B1CYP11B2 | |
| SCHEMBL11086479 | 0.70 | PDE3B (0.49) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL11083386 | 0.70 | PDE4A (0.52) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL10846502 | 0.70 | PDE3B (0.60) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL9527872 | 0.70 | PDE3B (0.67) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL11091508 | 0.70 | PDE4A (0.54) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL15964825 | 0.66 | MAPT (0.49) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL10665066 | 0.65 | PDE3B (0.54) | PDE3BPDE3AMAPTNPC1MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294647-B1 | THIADIAZINONES | MERCK PATENT GmbH (DE) | 1993-07-21 | — | — | EP | disclosed |
| EP-0294647-A2 | Thiadiazinones | MERCK PATENT GmbH (DE) | 1988-12-14 | — | — | EP | disclosed |