Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532290 | 0.94 | PDE3B (0.45) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL9532636 | 0.77 | HTR2A (0.33) | NPC1CYP11B1CYP11B2CRBNBRD4 | |
| SCHEMBL9527872 | 0.76 | PDE3B (0.67) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL9529954 | 0.70 | PDE3B (0.58) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL10647560 | 0.69 | PDE3B (0.54) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL10814980 | 0.69 | PDE3B (0.70) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL10902870 | 0.69 | PDE3B (1.00) | PDE3BPDE3AMAPTALDH1A1PDE4A | |
| SCHEMBL11092280 | 0.68 | PDE3B (0.53) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL11086856 | 0.67 | PDE4A (0.54) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL7274250 | 0.65 | PDE3B (0.61) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294647-B1 | THIADIAZINONES | MERCK PATENT GmbH (DE) | 1993-07-21 | — | — | EP | disclosed |
| US-4916128-A | Thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |
| EP-0294647-A2 | Thiadiazinones | MERCK PATENT GmbH (DE) | 1988-12-14 | — | — | EP | disclosed |