Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532628 | 0.77 | PDE3B (0.52) | CYP11B1CYP11B2NPC1CRBNBRD4 | |
| SCHEMBL9527882 | 0.75 | PDE3B (0.42) | HTR2ASRD5A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9532290 | 0.71 | PDE3B (0.45) | CYP11B1CYP11B2NPC1 | |
| SCHEMBL29495915 | 0.66 | GABRP (0.37) | HTR2ASRD5A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL22969568 | 0.66 | GABRP (0.37) | HTR2ASRD5A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8919270 | 0.65 | NPC1 (0.47) | HTR2ASRD5A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL16135231 | 0.63 | CYP11B2 (0.51) | SRD5A1CYP19A1CYP11B1CYP11B2NPC1 | |
| SCHEMBL10595981 | 0.62 | SMN1; SMN2 (0.49) | SRD5A1CYP19A1CYP11B1CYP11B2NPC1 | |
| SCHEMBL434004 | 0.61 | NPC1 (0.50) | SRD5A1CYP19A1CYP11B1CYP11B2NPC1 | |
| SCHEMBL12090742 | 0.61 | CYP19A1 (0.48) | CYP19A1CYP11B1CYP11B2NPC1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294647-B1 | THIADIAZINONES | MERCK PATENT GmbH (DE) | 1993-07-21 | — | — | EP | disclosed |