Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20826897 | 0.80 | KDM4E (0.50) | BACE1KDM4EALDH1A1POLBMAPT | |
| SCHEMBL7995598 | 0.80 | HSD17B10 (0.52) | BACE1KDM4EALDH1A1POLBMAPT | |
| SCHEMBL29663487 | 0.79 | BACE1 (0.40) | BACE1KDM4EALDH1A1POLBMAPT | |
| SCHEMBL31603 | 0.77 | BACE1 (0.44) | BACE1KDM4EALDH1A1POLBMAPT | |
| SCHEMBL28927137 | 0.77 | LMNA (0.54) | BACE1KDM4EALDH1A1POLBMAPT | |
| SCHEMBL31440186 | 0.76 | KDM4E (0.42) | BACE1KDM4EALDH1A1POLBMAPT | |
| SCHEMBL7243740 | 0.76 | PTPN1 (0.49) | BACE1KDM4EALDH1A1POLBMAPT | |
| SCHEMBL9533484 | 0.75 | TSHR (0.43) | BACE1KDM4EALDH1A1L3MBTL1POLB | |
| SCHEMBL3789174 | 0.75 | PTPN1 (0.51) | KDM4EALDH1A1POLBMAPTTSHR | |
| SCHEMBL3782935 | 0.75 | PTPN1 (0.51) | KDM4EALDH1A1POLBMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539372-A1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1991011448-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1991-08-08 | — | — | WO | disclosed |