Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | ACP1 | P24666 | 2/20 | 0.38 |
| ▸ | CDC25B | P30305 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28927137 | 0.89 | LMNA (0.54) | HSD17B10LMNABACE1ALDH1A1KDM4E | |
| SCHEMBL7243740 | 0.87 | PTPN1 (0.49) | HSD17B10LMNABACE1ALDH1A1KDM4E | |
| SCHEMBL3782935 | 0.86 | PTPN1 (0.51) | HSD17B10LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL31603 | 0.86 | BACE1 (0.44) | HSD17B10LMNABACE1ALDH1A1KDM4E | |
| SCHEMBL20826897 | 0.85 | KDM4E (0.50) | HSD17B10LMNABACE1ALDH1A1KDM4E | |
| SCHEMBL29663487 | 0.83 | BACE1 (0.40) | HSD17B10LMNABACE1ALDH1A1KDM4E | |
| SCHEMBL31440186 | 0.80 | KDM4E (0.42) | HSD17B10LMNABACE1ALDH1A1KDM4E | |
| SCHEMBL9532377 | 0.79 | PTPN1 (0.37) | HSD17B10BACE1PTPN1ACP1CDC25B | |
| SCHEMBL9533484 | 0.79 | TSHR (0.43) | HSD17B10LMNABACE1ALDH1A1KDM4E | |
| SCHEMBL9672041 | 0.79 | HSD17B10 (0.46) | HSD17B10LMNAALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020113209-A1 | PANTETHEINE DERIVATIVES AND USES THEREOF | COMET THERAPEUTICS, INC. (US) | 2020-06-04 | — | — | WO | disclosed |
| WO-2020113213-A2 | CYCLIC PANTETHEINE DERIVATIVES AND USES THEREOF | COMET THERAPEUTICS, INC. (US) | 2020-06-04 | — | — | WO | disclosed |
| US-20180086756-A1 | SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS | CHEMOCENTRYX, INC. | 2018-03-29 | — | — | US | disclosed |
| EP-2965758-B1 | OSTEOPONTIN PRODUCTION INHIBITOR COMPRISING DICTYOPYRONE DERIVATIVE OR DIHYDRODICTYOPYRONE DERIVATIVE AS ACTIVE INGREDIENT | UNIV TOHOKU (JP) | 2018-01-03 | — | — | EP | disclosed |
| US-9783540-B2 | Substituted tetrahydropyrans as CCR2 modulators | CHEMOCENTRYX, INC. (US) | 2017-10-10 | — | — | US | disclosed |
| US-20160340356-A1 | CCR2 MODULATORS | CHEMOCENTRYX, INC. | 2016-11-24 | — | — | US | disclosed |
| US-9463188-B2 | Osteopontin production inhibitor containing dictyopyrone derivative or dihydrodictyopyrone derivative as active ingredient | TOHOKU UNIVERSITY (JP) | 2016-10-11 | — | — | US | disclosed |
| EP-2965758-A1 | OSTEOPONTIN PRODUCTION INHIBITOR COMPRISING DICTYOPYRONE DERIVATIVE OR DIHYDRODICTYOPYRONE DERIVATIVE AS ACTIVE INGREDIENT | Tohoku University (JP) | 2016-01-13 | — | — | EP | disclosed |
| CN-105209038-A | Osteopontin production inhibitor comprising dictyopyrone derivative or dihydrodictyopyrone derivative as active ingredient | UNIV TOHOKU NAT UNIV CORP | 2015-12-30 | — | — | CN | disclosed |
| US-20150366851-A1 | OSTEOPONTIN PRODUCTION INHIBITOR CONTAINING DICTYOPYRONE DERIVATIVE OR DIHYDRODICTYOPYRONE DERIVATIVE AS ACTIVE INGREDIENT | TOHOKU UNIVERSITY (JP) | 2015-12-24 | — | — | US | disclosed |
| WO-2014136161-A1 | OSTEOPONTIN PRODUCTION INHIBITOR COMPRISING DICTYOPYRONE DERIVATIVE OR DIHYDRODICTYOPYRONE DERIVATIVE AS ACTIVE INGREDIENT | 国立大学法人東北大学 (JP) | 2014-09-12 | — | — | WO | disclosed |
| US-20130252943-A1 | BICYCLIC OXAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-09-26 | — | — | US | disclosed |
| WO-2001017977-A1 | 1,3,5-TRIAZINES AS HERBICIDES | NIHON BAYER AGROCHEM K.K. (JP) | 2001-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252943-A1 | BICYCLIC OXAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | GRM5, GRIK5, GRM1 | HSD17B10 2257/4885LMNA 4790/4885BACE1 589/4885 |
| US-20180086756-A1 | SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS | CCR2, CCR1, CCR5 | HSD17B10 2291/4885LMNA 4778/4885BACE1 3587/4885 |
| US-20150366851-A1 | OSTEOPONTIN PRODUCTION INHIBITOR CONTAINING DICTYOPYRONE DERIVATIVE OR DIHYDRODICTYOPYRONE DERIVATIVE AS ACTIVE INGREDIENT | SPPL2B, DPYSL3, DIAPH1 | HSD17B10 525/4885LMNA 3434/4885BACE1 161/4885 |
| US-20160340356-A1 | CCR2 MODULATORS | CCR2, CCR1, CCR5 | HSD17B10 1987/4885LMNA 4371/4885BACE1 3571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.