Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7997728 | 0.83 | HMGB1 (0.35) | GSK3BMEN1KMT2AALDH1A1HSP90AB1 | |
| SCHEMBL15698069 | 0.83 | HSP90AB1 (0.42) | MEN1KMT2AALDH1A1GAAHSP90AB1 | |
| SCHEMBL4984920 | 0.81 | GSK3B (0.41) | GSK3BMEN1KMT2AALDH1A1GAA | |
| SCHEMBL9278783 | 0.79 | MAPT (0.38) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL865601 | 0.78 | MEN1 (0.36) | GSK3BMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL11328772 | 0.77 | GAA (0.42) | MEN1KMT2AALDH1A1GAAHSD17B10 | |
| SCHEMBL7787256 | 0.76 | KMT2A (0.37) | MEN1KMT2AALDH1A1GAAHSP90AB1 | |
| SCHEMBL9632558 | 0.76 | HTT (0.40) | ALDH1A1GAAKDM4EHPGDHSD17B10 | |
| SCHEMBL3939543 | 0.76 | LMNA (0.42) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL10607897 | 0.75 | MAPT (0.40) | MEN1KMT2AALDH1A1GAAHSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277836-B1 | THIAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-06-02 | — | — | EP | disclosed |
| US-4873255-A | REDUCE BLOOD GLUCOSE AND BLOOD LIPID LEVELS | SANKYO COMPANY LIMITED (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0277836-A1 | Thiazolidinone derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-08-10 | — | — | EP | disclosed |