Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGB1 | P09429 | 1/20 | 0.35 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | TCF4 | P15884 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | FASN | P49327 | 2/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532477 | 0.83 | GSK3B (0.32) | HSD17B10KDM4EMEN1KMT2AHSP90AB1 | |
| SCHEMBL10607897 | 0.80 | MAPT (0.40) | HMGB1CXCL12CA1CA2HSD17B10 | |
| SCHEMBL11328772 | 0.74 | GAA (0.42) | HSD17B10MAPTMEN1KMT2ARAB9A | |
| SCHEMBL11542741 | 0.73 | ALDH1A1 (0.43) | HSD17B10MAPTKDM4EMEN1KMT2A | |
| SCHEMBL27718800 | 0.73 | ALDH1A1 (0.47) | CA1CA2HSD17B10MAPTKDM4E | |
| SCHEMBL25405819 | 0.73 | L3MBTL1 (0.42) | HMGB1CXCL12CA1CA2MAPT | |
| SCHEMBL3939543 | 0.73 | LMNA (0.42) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL9632558 | 0.73 | HTT (0.40) | HSD17B10MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL30496176 | 0.72 | NR2F2 (0.41) | HMGB1CXCL12CA2KDM4EMEN1 | |
| SCHEMBL11106707 | 0.72 | MAPT (0.42) | MAPTKDM4EMEN1KMT2AFASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000010994-A1 | PROCESS FOR THE PREPARATION OF 2-(ARYLOXYMETHYL)-2,5,7,8-TETRAMETHYLCHROMAN-6-OLS | SANKYO COMPANY, LIMITED (JP) | 2000-03-02 | — | — | WO | disclosed |
| US-5104888-A | Anticholesterol or antidiabetic agents | SANKYO COMPANY, LIMITED (JP) | 1992-04-14 | — | — | US | disclosed |
| EP-0207581-B1 | THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND USE | SANKYO COMPANY LIMITED (JP) | 1990-09-12 | — | — | EP | disclosed |
| EP-0139421-B1 | THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1988-04-27 | — | — | EP | disclosed |
| EP-0207581-A2 | Thiazolidine derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1987-01-07 | — | — | EP | disclosed |
| US-4572912-A | Thiazolidine derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1986-02-25 | — | — | US | disclosed |
| EP-0139421-A1 | Thiazolidine derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1985-05-02 | — | — | EP | disclosed |
| US-4479007-A | Chroman-4-ones and process for preparing same | BAYER AKTIENGESELLSCHAFT (DE) | 1984-10-23 | — | — | US | disclosed |
| US-4415741-A | REACTING O-HYDROXYACETOPHENONE AND CYCLOPENTANONE | BAYER AKTIENGESELLSCHAFT (DE) | 1983-11-15 | — | — | US | disclosed |