Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 13/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 3/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533019 | 0.90 | LTB4R (0.37) | LTB4RCYSLTR2CYSLTR1 | |
| SCHEMBL9532505 | 0.84 | LTB4R (0.54) | LTB4RMAPTRXFP1CES1NCEH1 | |
| SCHEMBL9532623 | 0.83 | CYSLTR2 (0.48) | LTB4RMAPTRXFP1CYSLTR2CYSLTR1 | |
| SCHEMBL9535430 | 0.73 | CYSLTR2 (0.44) | LTB4RCYSLTR2CYSLTR1 | |
| SCHEMBL9533860 | 0.69 | CYSLTR2 (0.48) | MAPTRXFP1CES1NCEH1CYSLTR2 | |
| SCHEMBL9534374 | 0.66 | CYSLTR2 (0.68) | LTB4RMAPTRXFP1CYSLTR2CYSLTR1 | |
| SCHEMBL9537456 | 0.66 | LTB4R (0.58) | LTB4RMAPTRXFP1CES1CYSLTR2 | |
| SCHEMBL9532869 | 0.65 | CYSLTR2 (0.69) | LTB4RMAPTRXFP1CYSLTR2CYSLTR1 | |
| SCHEMBL18956278 | 0.64 | MEN1 (0.52) | — | |
| SCHEMBL7819517 | 0.63 | DAO (0.50) | CES1NCEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528957-A4 | FIVE-MEMBERED RING ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | — | 1993-05-05 | — | — | EP | disclosed |
| EP-0528957-A1 | FIVE-MEMBERED RING ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-03-03 | — | — | EP | disclosed |
| WO-1991016889-A1 | FIVE-MEMBERED RING ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-11-14 | — | — | WO | disclosed |