SCHEMBL9532543

SCHEMBL9532543

OC(C=Cc1ccc(F)cc1)Cn1cncn1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 6/20 0.46
KMT2A Q03164 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
LMNA P02545 1/20 0.39
HSP90AA1 P07900 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP11B1 P15538 1/20 0.39
CYP11B2 P19099 1/20 0.39
CYP2C19 P33261 1/20 0.39
ADRA1A P35348 1/20 0.39
CYP51A1 Q16850 1/20 0.39
POLB P06746 1/20 0.39
HPGD P15428 1/20 0.39
MC3R P41968 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
NFE2L2 Q16236 1/20 0.35
PTGS1 P23219 1/20 0.35
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11635372 0.75 CYP19A1 (0.48) CYP19A1KMT2ALMNACYP3A4CYP11B1
SCHEMBL11635373 0.75 CYP19A1 (0.48) CYP19A1KMT2ALMNACYP3A4CYP11B1
SCHEMBL11273790 0.75 CYP19A1 (0.59) CYP19A1KMT2ALMNAHSP90AA1CYP3A4
SCHEMBL28440269 0.75 KMT2A (0.49) KMT2ASMN1; SMN2LMNAHPGDALDH1A1
SCHEMBL29430299 0.72 EGLN3 (0.41) CYP19A1KMT2APOLBHPGD
SCHEMBL27584580 0.71 CYP19A1 (0.50) CYP19A1KMT2ASMN1; SMN2LMNAHSP90AA1
SCHEMBL27602502 0.70 CYP19A1 (0.56) CYP19A1KMT2ASMN1; SMN2LMNAHSP90AA1
SCHEMBL9695247 0.69 CYP19A1 (0.59) CYP19A1KMT2ALMNAHSP90AA1CYP3A4
SCHEMBL11275601 0.69 CYP19A1 (0.59) CYP19A1KMT2ALMNAHSP90AA1CYP3A4
SCHEMBL8813815 0.69 EGLN3 (0.43) CYP19A1HSP90AA1POLBHPGDHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0251086-B1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-03-17 EP disclosed
US-5084465-A Plant fungicides for agriculture DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-01-28 US disclosed
EP-0440608-A1 ANTIFUNGAL CARBINOLS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-08-14 EP disclosed
US-4980367-A CONTROLLING PLANT DISEASES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-12-25 US disclosed
US-4952232-A Antifungal carbinols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-28 US disclosed
WO-1989005801-A1 ANTIFUNGAL CARBINOLS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-29 WO disclosed
EP-0321211-A1 Antifungal carbinols E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-21 EP disclosed