Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9790164 | 1.00 | SLC6A2 (0.54) | SLC6A2SLC6A4KCNH2HTR3AHTR4 | |
| SCHEMBL9790170 | 1.00 | SLC6A2 (0.54) | SLC6A2SLC6A4KCNH2HTR3AHTR4 | |
| SCHEMBL10107504 | 0.89 | HTR3A (0.63) | HTR3AHTR4RAB9AMEN1KMT2A | |
| SCHEMBL10122269 | 0.89 | HTR3A (0.63) | HTR3AHTR4RAB9AMEN1KMT2A | |
| SCHEMBL9790068 | 0.88 | HTR3A (0.58) | SLC6A2SLC6A4KCNH2HTR3AHTR4 | |
| SCHEMBL9790063 | 0.88 | HTR3A (0.58) | SLC6A2SLC6A4KCNH2HTR3AHTR4 | |
| SCHEMBL9790077 | 0.88 | HTR3A (0.58) | SLC6A2SLC6A4KCNH2HTR3AHTR4 | |
| SCHEMBL9721683 | 0.81 | HTR3A (0.53) | HTR3AHTR4GAASSTR1SSTR4 | |
| SCHEMBL9721673 | 0.81 | HTR3A (0.53) | HTR3AHTR4GAASSTR1SSTR4 | |
| SCHEMBL9721577 | 0.81 | HTR3A (0.53) | HTR3AHTR4GAASSTR1SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251417-B1 | 4-(AROYLAMINO) PIPERIDINEBUTANAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-04-14 | — | — | EP | disclosed |
| US-4990521-A | Treating diarhea | JANSSEN PHARMACEUTICA (BE) | 1991-02-05 | — | — | US | disclosed |
| EP-0251417-A2 | 4-(aroylamino) piperidinebutanamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-01-07 | — | — | EP | disclosed |