Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.58 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | STK39 | Q9UEW8 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 6/20 | 0.41 |
| ▸ | HTR2B | P41595 | 6/20 | 0.41 |
| ▸ | AHCY | P23526 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9790068 | 1.00 | HTR3A (0.58) | HTR3AHTR4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL9790077 | 1.00 | HTR3A (0.58) | HTR3AHTR4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL9532735 | 0.88 | SLC6A2 (0.54) | HTR3AHTR4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL9790164 | 0.88 | SLC6A2 (0.54) | HTR3AHTR4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL9790170 | 0.88 | SLC6A2 (0.54) | HTR3AHTR4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL10122269 | 0.77 | HTR3A (0.63) | HTR3AHTR4 | |
| SCHEMBL10107504 | 0.77 | HTR3A (0.63) | HTR3AHTR4 | |
| SCHEMBL9721673 | 0.76 | HTR3A (0.53) | HTR3AHTR4 | |
| SCHEMBL9721683 | 0.76 | HTR3A (0.53) | HTR3AHTR4 | |
| SCHEMBL9721577 | 0.76 | HTR3A (0.53) | HTR3AHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990521-A | Treating diarhea | JANSSEN PHARMACEUTICA (BE) | 1991-02-05 | — | — | US | disclosed |
| EP-0251417-A2 | 4-(aroylamino) piperidinebutanamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-01-07 | — | — | EP | disclosed |