Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066028 | 0.84 | KDM4E (0.40) | ACHENPSR1MAPTGAAKMT2A | |
| SCHEMBL28791191 | 0.81 | TDP1 (0.41) | TDP1NPSR1MAPTGAAKMT2A | |
| SCHEMBL10397232 | 0.81 | PARP1 (0.44) | MAPTKDM4EPDE10ADDAH1POLB | |
| SCHEMBL31345731 | 0.80 | POLB (0.40) | TDP1NPSR1ALDH1A1RAB9ALMNA | |
| SCHEMBL22333123 | 0.80 | TDP1 (0.40) | TDP1NPSR1MAPTKMT2AALDH1A1 | |
| SCHEMBL25369555 | 0.80 | TDP1 (0.47) | TDP1NPSR1MAPTKMT2ARAB9A | |
| SCHEMBL31345698 | 0.80 | TDP1 (0.47) | TDP1NPSR1MAPTKMT2ARAB9A | |
| SCHEMBL5204337 | 0.80 | TDP1 (0.40) | TDP1NPSR1GAAKMT2AALDH1A1 | |
| SCHEMBL3938947 | 0.80 | TDP1 (0.40) | TDP1NPSR1MAPTGAAKMT2A | |
| SCHEMBL11195012 | 0.80 | PARP1 (0.43) | TDP1MAPTGAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266326-B1 | NOVEL DERIVATIVES OF BENZIMIDAZOLES ACTIVE AS ANTI-ULCER AGENTS | Aktiebolaget Hässle (SE) | 1993-03-10 | — | — | EP | disclosed |
| US-5106862-A | DERIVATIVES OF BENZIMIDAZOLES ACTIVE AS ANTI-ULCER AGENTS | AKTIEBOLAGET HASSLE (SE) | 1992-04-21 | — | — | US | disclosed |