Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | HTR1D | P28221 | 8/20 | 0.50 |
| ▸ | HTR1B | P28222 | 7/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9776420 | 0.94 | HTR1A (0.53) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL6890172 | 0.88 | HTR1A (0.65) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL9534913 | 0.88 | HTR1A (0.50) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL7716614 | 0.87 | HTR1A (0.64) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL9776382 | 0.87 | HTR1A (0.49) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL10340387 | 0.84 | HTR1A (0.60) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL9534014 | 0.84 | HTR1A (0.56) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL9531561 | 0.83 | HTR1A (0.59) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL9536727 | 0.83 | HTR1A (0.57) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL9776435 | 0.82 | HTR1D (0.44) | HTR1AHTR1DHTR1BMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021438-A | Having affinity for 5-hydroxytryptamine receptors; treating central nervous system and cardiovascular disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-06-04 | — | — | US | claimed |
| EP-0332968-B1 | 1,3,4,5-Tetrahydrobenz[c,d]indoles | BAYER AG (DE) | 1993-06-02 | — | — | EP | disclosed |
| US-5021438-A | Having affinity for 5-hydroxytryptamine receptors; treating central nervous system and cardiovascular disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0332968-A1 | 1,3,4,5-Tetrahydrobenz[c,d]indoles | BAYER AG (DE) | 1989-09-20 | — | — | EP | disclosed |