Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | HTR1D | P28221 | 8/20 | 0.51 |
| ▸ | HTR1B | P28222 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021107 | 0.98 | HTR1A (0.56) | HTR1AHTR1DHTR1BALDH1A1CYP2D6 | |
| SCHEMBL6890172 | 0.95 | HTR1A (0.65) | HTR1AHTR1DHTR1BALDH1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL7716614 | 0.94 | HTR1A (0.64) | HTR1AHTR1DHTR1BALDH1A1CYP2D6 | |
| SCHEMBL9531561 | 0.90 | HTR1A (0.59) | HTR1AHTR1DHTR1BALDH1A1CYP2D6 | |
| SCHEMBL9776420 | 0.86 | HTR1A (0.53) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL9534053 | 0.86 | HTR1A (0.54) | HTR1AHTR1DHTR1BALDH1A1CYP2D6 | |
| SCHEMBL11019525 | 0.86 | MTNR1A (0.54) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL9534014 | 0.85 | HTR1A (0.56) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL9533189 | 0.84 | HTR1A (0.55) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL9356973 | 0.82 | HTR1A (0.66) | HTR1AHTR1DHTR1BMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162695-B1 | 6-OXYGENATED-1,3,,4,5-TETRAHYDROBENZ(CD)INDOL-4-AMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-17 | — | — | EP | disclosed |
| EP-0162695-A1 | 6-Oxygenated-1,3,,4,5-Tetrahydrobenz(cd)indol-4-amines | SMITHKLINE BEECHAM CORPORATION (US) | 1985-11-27 | — | — | EP | disclosed |