Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.44 |
| ▸ | ABAT | P80404 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3543624 | 0.82 | ALDH1A1 (0.46) | MAPTMAPK1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL29484215 | 0.82 | MAPT (0.67) | MAPTMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL4368126 | 0.82 | MAPT (0.67) | MAPTMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL29878741 | 0.80 | CRHBP (0.68) | MAPTMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL3559913 | 0.80 | CRHBP (0.68) | MAPTMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL28537073 | 0.79 | CRHBP (0.66) | MAPTMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL3535307 | 0.79 | MAPT (0.44) | MAPTALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL9306308 | 0.78 | MAPT (0.62) | MAPTMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL9318576 | 0.75 | CRHBP (0.65) | MAPTMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL3299033 | 0.74 | TSHR (0.53) | MAPTALDH1A1TSHRSMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241043-B1 | NOVEL DIARYLALKANOIDS HAVING ACTIVITY AS LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5177259-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1993-01-05 | — | — | US | disclosed |
| US-5142095-A | Treating inflammation, allergies, asthma, cardiovascular disorders, psoriasis | WARNER-LAMBERT COMPANY (US) | 1992-08-25 | — | — | US | disclosed |
| US-5077411-A | Antiallergens, antiinflammatory agents; cardiovascular disorders, migraines, psoriasis | WARNER-LAMBERT CO. (US) | 1991-12-31 | — | — | US | disclosed |
| US-4959503-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1990-09-25 | — | — | US | disclosed |
| US-4810716-A | ANTIINFLAMMATORY, ANTIALLERGY, ANTIISCHEMIC | WARNER-LAMBERT COMPANY (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0241043-A2 | Novel diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1987-10-14 | — | — | EP | disclosed |