Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533244 | 1.00 | AGTR1 (0.38) | AGTR1AGTR2KMT2A | |
| SCHEMBL9554409 | 0.92 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL9554407 | 0.92 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL9734093 | 0.91 | KMT2A (0.34) | AGTR1AGTR2KMT2A | |
| SCHEMBL9734099 | 0.91 | KMT2A (0.34) | AGTR1AGTR2KMT2A | |
| SCHEMBL9554614 | 0.88 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL9553748 | 0.88 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL9553746 | 0.88 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL9529754 | 0.87 | AGTR1 (0.40) | AGTR1AGTR2KMT2A | |
| SCHEMBL9530953 | 0.86 | AGTR1 (0.45) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5238952-A | Treating glaucoma disorders | G. D. SEARLE & CO. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0555331-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS. | SEARLE & CO (US) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992007834-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |