Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 10/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.33 |
| ▸ | OGG1 | O15527 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2255444 | 0.81 | ALDH1A1 (0.41) | HTR1BALDH1A1L3MBTL1HTR1D | |
| SCHEMBL8681171 | 0.79 | HTR1B (0.46) | HTR1BTDP1L3MBTL1HTR1DSLC6A4 | |
| SCHEMBL6041472 | 0.79 | MAPT (0.49) | ALDH1A1HPGDTDP1L3MBTL1 | |
| SCHEMBL2253601 | 0.77 | HTR1B (0.50) | HTR1BKCNA3TDP1L3MBTL1HTR1D | |
| SCHEMBL5888930 | 0.77 | HPGD (0.48) | KDM4EALDH1A1HPGD | |
| SCHEMBL28372071 | 0.77 | HTR1B (0.44) | HTR1BKCNA3TDP1HTR1DSLC6A4 | |
| SCHEMBL10499954 | 0.76 | HTR1B (0.60) | HTR1BKDM4EKCNA3ALDH1A1HPGD | |
| SCHEMBL2806197 | 0.76 | HTR1B (0.43) | HTR1BKCNA3HTR1DSLC6A4HRH1 | |
| SCHEMBL155614 | 0.75 | MAPT (0.48) | KDM4EALDH1A1HPGDTDP1SLC6A4 | |
| SCHEMBL8702780 | 0.72 | KMT2A (0.41) | KDM4EKCNA3ALDH1A1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549600-A1 | 5-TRIFLUOROACYLAMINO-2-ARYL OXAZOLES | PFIZER INC. (US) | 1993-07-07 | — | — | EP | claimed |
| WO-1992005163-A1 | 5-TRIFLUOROACYLAMINO-2-ARYL OXAZOLES | PFIZER INC. (US) | 1992-04-02 | — | — | WO | claimed |
| EP-0549600-A1 | 5-TRIFLUOROACYLAMINO-2-ARYL OXAZOLES | PFIZER INC. (US) | 1993-07-07 | — | — | EP | disclosed |
| WO-1992005163-A1 | 5-TRIFLUOROACYLAMINO-2-ARYL OXAZOLES | PFIZER INC. (US) | 1992-04-02 | — | — | WO | disclosed |