Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | RYR2 | Q92736 | 6/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10382676 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL10382673 | 0.81 | LMNA (0.56) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL345330 | 0.77 | SMN1; SMN2 (0.81) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL27188923 | 0.77 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL9537213 | 0.69 | RYR2 (0.46) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL9534884 | 0.68 | RYR2 (0.44) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL8118067 | 0.67 | RYR2 (0.56) | KDM4EALDH1A1LMNARYR2CA1 | |
| SCHEMBL19469587 | 0.67 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNA | |
| SCHEMBL5403243 | 0.67 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL19469584 | 0.67 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539372-A1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1991011448-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1991-08-08 | — | — | WO | disclosed |