Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534884 | 0.87 | RYR2 (0.44) | RYR2KDM4ESMN1; SMN2MAPTACHE | |
| SCHEMBL12276706 | 0.85 | RYR2 (0.45) | RYR2KDM4ESMN1; SMN2MAPTACHE | |
| SCHEMBL10383075 | 0.84 | KDM4E (0.49) | KDM4ESMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL10382352 | 0.84 | KDM4E (0.48) | KDM4ESMN1; SMN2MAPTACHEHTT | |
| SCHEMBL14714 | 0.80 | PPARG (0.41) | RYR2KDM4ESMN1; SMN2MAPTACHE | |
| SCHEMBL5141716 | 0.80 | ALDH1A1 (0.40) | KDM4ESMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL12264722 | 0.79 | ACHE (0.56) | RYR2KDM4EACHEHTTLMNA | |
| SCHEMBL31562781 | 0.76 | ACHE (0.61) | KDM4EMAPTACHEALDH1A1HPGD | |
| SCHEMBL385595 | 0.76 | ACHE (0.61) | KDM4EMAPTACHEALDH1A1HPGD | |
| SCHEMBL12275937 | 0.75 | KDM4E (0.48) | RYR2KDM4ESMN1; SMN2ACHEHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539372-A1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1991011448-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1991-08-08 | — | — | WO | disclosed |