Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 3/20 | 0.59 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.53 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.48 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.48 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.48 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.48 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.48 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.48 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.48 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.48 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.48 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.48 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443260 | 1.00 | CTSD (0.59) | CTSDPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6449655 | 0.94 | CTSD (0.66) | CTSDPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15095216 | 0.93 | CTSD (0.67) | CTSDPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9237787 | 0.92 | CTSD (0.58) | CTSDPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9237792 | 0.92 | CTSD (0.58) | CTSDPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6447745 | 0.92 | CTSD (0.66) | CTSDPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7270278 | 0.91 | CTSD (0.67) | CTSDPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7430958 | 0.88 | BACE1 (0.61) | CTSDKLK5BACE1 | |
| SCHEMBL8531207 | 0.87 | KLK5 (0.61) | CTSDPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8532173 | 0.87 | KLK5 (0.61) | CTSDPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532693-A1 | 1,4-DIAMINO-2,3-DIHYDROXYBUTANES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-24 | — | — | EP | claimed |