Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2725217 | 0.84 | HSP90AA1 (0.59) | TSHRHSD17B10KMOHSP90AA1HSP90AB1 | |
| SCHEMBL21055987 | 0.84 | GSK3B (0.55) | TSHRALDH1A1CYP3A4HSD17B10TDP1 | |
| SCHEMBL1362599 | 0.83 | TSHR (0.59) | TSHRALDH1A1KMOPOLBHPGD | |
| SCHEMBL9618646 | 0.82 | TSHR (0.43) | TSHRALDH1A1CYP3A4HSD17B10TDP1 | |
| SCHEMBL31509307 | 0.81 | CA12 (0.58) | TDP1POLBPLAA | |
| SCHEMBL105705 | 0.81 | CA12 (0.58) | TDP1POLBPLAA | |
| SCHEMBL30467135 | 0.80 | KCNQ3 (0.47) | TSHRKMOPOLBHPGDHTT | |
| SCHEMBL6559766 | 0.80 | KCNQ3 (0.47) | TSHRKMOPOLBHPGDHTT | |
| SCHEMBL11637468 | 0.79 | USP5 (0.50) | TSHRALDH1A1HSD17B10HPGD | |
| SCHEMBL16185986 | 0.79 | NPC1 (0.49) | TSHRALDH1A1HSP90AB1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277836-B1 | THIAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-06-02 | — | — | EP | disclosed |
| US-4873255-A | REDUCE BLOOD GLUCOSE AND BLOOD LIPID LEVELS | SANKYO COMPANY LIMITED (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0277836-A1 | Thiazolidinone derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-08-10 | — | — | EP | disclosed |