Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 9/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9432478 | 0.70 | AKR1B1 (0.53) | AKR1B1OPRM1OPRD1OPRK1 | |
| SCHEMBL9432167 | 0.66 | AKR1B1 (0.44) | AKR1B1OPRM1OPRD1OPRK1 | |
| SCHEMBL9432976 | 0.64 | AKR1B1 (0.47) | AKR1B1OPRM1OPRD1OPRK1 | |
| SCHEMBL5708359 | 0.63 | LMNA (1.00) | LMNAL3MBTL1HRH4HRH3 | |
| SCHEMBL1269358 | 0.63 | LMNA (1.00) | LMNAL3MBTL1HRH4HRH3 | |
| SCHEMBL18844035 | 0.63 | LMNA (1.00) | LMNAL3MBTL1HRH4HRH3 | |
| SCHEMBL3142790 | 0.62 | LMNA (0.63) | LMNAL3MBTL1HRH4HRH3 | |
| SCHEMBL10120126 | 0.61 | LMNA (0.51) | LMNAL3MBTL1HRH4HRH3 | |
| SCHEMBL9257211 | 0.61 | AKR1B1 (0.66) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9774876 | 0.60 | LMNA (0.50) | LMNAL3MBTL1HRH4HRH3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530198-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1991015491-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |