Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 6/20 | 0.49 |
| ▸ | DHFR | P00374 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ATIC | P31939 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534086 | 1.00 | GART (0.49) | GARTDHFRKDM4EALDH1A1HPGD | |
| SCHEMBL9050434 | 0.92 | GART (0.48) | GARTDHFRKDM4EALDH1A1HPGD | |
| SCHEMBL9050424 | 0.92 | GART (0.48) | GARTDHFRKDM4EALDH1A1HPGD | |
| SCHEMBL9383606 | 0.90 | GART (0.56) | GARTDHFRKDM4EALDH1A1HPGD | |
| SCHEMBL9383614 | 0.90 | GART (0.56) | GARTDHFRKDM4EALDH1A1HPGD | |
| SCHEMBL9048299 | 0.88 | GART (0.44) | GARTDHFRKDM4EALDH1A1HPGD | |
| SCHEMBL9048289 | 0.88 | GART (0.44) | GARTDHFRKDM4EALDH1A1HPGD | |
| SCHEMBL10494144 | 0.88 | KDM4E (0.40) | GARTDHFRKDM4EALDH1A1HPGD | |
| SCHEMBL10494147 | 0.88 | KDM4E (0.40) | GARTDHFRKDM4EALDH1A1HPGD | |
| SCHEMBL10512971 | 0.86 | GART (0.58) | GARTDHFRKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215063-B1 | PYRIDO (2,3-d )PYRIMIDIN DERIVATIVES | UNIV PRINCETON (US) | 1993-11-03 | — | — | EP | disclosed |
| US-5026851-A | Antineoplastic agents | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-25 | — | — | US | disclosed |
| US-4927828-A | ANTITUMOR | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1990-05-22 | — | — | US | disclosed |
| US-4845216-A | ANTITUMOR AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-07-04 | — | — | US | disclosed |
| EP-0248573-A2 | Diastereoisomeric tetrahydropyrido(2,3-d)pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1987-12-09 | — | — | EP | disclosed |
| US-4684653-A | ANTITUMOR AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1987-08-04 | — | — | US | disclosed |