Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SLC26A6 | Q9BXS9 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14783064 | 0.88 | ALDH1A1 (0.46) | ALDH1A1TSHRHSD17B10MAPTPOLB | |
| SCHEMBL64663 | 0.88 | ALDH1A1 (0.51) | ALDH1A1TSHRHSD17B10MAPTPOLB | |
| SCHEMBL20351618 | 0.85 | ALDH1A1 (0.49) | ALDH1A1TSHRHSD17B10MAPTPOLB | |
| SCHEMBL6641439 | 0.81 | CYP4F2 (0.55) | ALDH1A1TSHRHSD17B10MAPTPOLB | |
| SCHEMBL17016715 | 0.80 | ALDH1A1 (0.44) | ALDH1A1TSHRHSD17B10MAPTPOLB | |
| SCHEMBL12530216 | 0.79 | ALDH1A1 (0.47) | ALDH1A1HSD17B10MAPTPOLBHPGD | |
| SCHEMBL11011624 | 0.79 | ALDH1A1 (0.48) | ALDH1A1HSD17B10MAPTPOLBUSP2 | |
| SCHEMBL5883913 | 0.78 | ALDH1A1 (0.50) | ALDH1A1TSHRHSD17B10MAPTPOLB | |
| SCHEMBL27581979 | 0.78 | MMP12 (0.49) | ALDH1A1TSHRHSD17B10MAPTPOLB | |
| SCHEMBL1645027 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRHSD17B10MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241043-B1 | NOVEL DIARYLALKANOIDS HAVING ACTIVITY AS LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5177259-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1993-01-05 | — | — | US | disclosed |
| US-5077411-A | Antiallergens, antiinflammatory agents; cardiovascular disorders, migraines, psoriasis | WARNER-LAMBERT CO. (US) | 1991-12-31 | — | — | US | disclosed |
| US-4959503-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1990-09-25 | — | — | US | disclosed |