Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MDH2 | P40926 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10563639 | 0.88 | STAT3 (0.50) | STAT3HSP90AA1 | |
| SCHEMBL584832 | 0.83 | GSK3B (0.61) | GSK3BALDH1A1HPGDTOP2ATOP2B | |
| SCHEMBL6213203 | 0.77 | KDM4E (0.51) | STAT3TOP1ALDH1A1HPGDTOP2A | |
| SCHEMBL9617336 | 0.74 | MAPT (0.52) | ALDH1A1HPGDCTSVCTSLLMNA | |
| SCHEMBL583970 | 0.73 | ADRB2 (0.54) | STAT3GSK3BALDH1A1TOP2ATOP2B | |
| SCHEMBL10559409 | 0.73 | STAT3 (0.47) | STAT3HSP90AA1 | |
| SCHEMBL8736415 | 0.72 | CHRM1 (0.53) | TOP1CHRM1LMNAMAPT | |
| SCHEMBL7009985 | 0.72 | CHRM1 (0.61) | TOP1CHRM1KDM4ELMNAMAPT | |
| SCHEMBL10560775 | 0.72 | STAT3 (0.46) | STAT3HSP90AA1MAPT | |
| SCHEMBL9569160 | 0.69 | TOP1 (0.48) | STAT3TOP1ALDH1A1TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259804-B1 | Pyrido[3,2,1-ij]-1,3,4-benzoxadiazine derivatives, process for their preparation, resulting pharmaceutical preparations and intermediates for use in the process | HOFFMANN LA ROCHE (CH) | 1993-11-18 | — | — | EP | disclosed |
| EP-0259804-A2 | Pyrido[3,2,1-ij]-1,3,4-benzoxadiazine derivatives, process for their preparation, resulting pharmaceutical preparations and intermediates for use in the process | F. HOFFMANN-LA ROCHE AG (CH) | 1988-03-16 | — | — | EP | disclosed |