Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533383 | 0.82 | GPBAR1 (0.51) | GPBAR1GABRA5FFAR4 | |
| SCHEMBL9535597 | 0.80 | NR1H4 (0.53) | NR1H4 | |
| SCHEMBL9535705 | 0.78 | GPBAR1 (0.48) | GPBAR1GABRA5FFAR4SMN1; SMN2 | |
| SCHEMBL9535545 | 0.76 | FFAR4 (0.50) | GPBAR1GABRA5FFAR4SMN1; SMN2 | |
| SCHEMBL9533125 | 0.75 | KMT2A (0.48) | GPBAR1SMN1; SMN2NR1H4ALDH1A1 | |
| SCHEMBL9535701 | 0.69 | KMT2A (0.54) | GPBAR1SMN1; SMN2 | |
| SCHEMBL29142635 | 0.68 | GABRA5 (0.50) | GPBAR1THRBGABRA5SMN1; SMN2ALDH1A1 | |
| SCHEMBL29142636 | 0.68 | GABRA5 (0.50) | GPBAR1THRBGABRA5SMN1; SMN2ALDH1A1 | |
| SCHEMBL11519685 | 0.67 | KMT2A (0.51) | GPBAR1SMN1; SMN2NR1H4 | |
| SCHEMBL27565925 | 0.66 | GPBAR1 (0.40) | GPBAR1THRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573883-A1 | Utilization of 3 substituted aryl-5-alkyl-isoxazole-4-carboxylic acid derivatives against endoparasites new 3-substituted aryl-5-alkyl-isoxazole-4-carboxylic acid derivatives and process for their preparation | BAYER AG (DE) | 1993-12-15 | — | — | EP | disclosed |