Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533660 | 0.88 | HDAC8 (0.36) | MAPTALDH1A1HDAC8LMNATP53 | |
| SCHEMBL9534186 | 0.86 | TSHR (0.44) | KDM4EMAPTHDAC8LMNATP53 | |
| SCHEMBL9532968 | 0.83 | TSHR (0.50) | KDM4EMAPTL3MBTL1ALDH1A1LMNA | |
| SCHEMBL9537414 | 0.73 | TSHR (0.46) | KDM4EMAPTALDH1A1MAPK1HDAC8 | |
| SCHEMBL9534591 | 0.72 | MAPT (0.38) | KDM4EMAPTL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL11706050 | 0.72 | CA9 (0.41) | KDM4EMAPTL3MBTL1ALDH1A1PRKDC | |
| SCHEMBL9533704 | 0.71 | TSHR (0.51) | MAPTL3MBTL1ALDH1A1MAPK1LMNA | |
| SCHEMBL9532198 | 0.70 | TSHR (0.53) | MAPTL3MBTL1ALDH1A1MAPK1LMNA | |
| SCHEMBL9533307 | 0.69 | TSHR (0.52) | ALDH1A1LMNATP53TSHRHSD17B10 | |
| SCHEMBL9533982 | 0.69 | TSHR (0.52) | ALDH1A1LMNATP53TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0360261-B1 | Substituted Imidazol[2,1-b] quinazolin-5(3H)-ones and related tricyclic compounds | MERRELL DOW PHARMA (US) | 1993-10-27 | — | — | EP | disclosed |
| EP-0360261-A1 | Substituted Imidazol[2,1-b] quinazolin-5(3H)-ones and related tricyclic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-28 | — | — | EP | disclosed |
| US-4871732-A | Substituted imidazo(2,1-b)quinazolin-5(3H)-ones and related tricyclic compounds and use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-03 | — | — | US | disclosed |