Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534186 | 0.88 | TSHR (0.44) | TSHRSMARCA2KDM4ELMNAHTT | |
| SCHEMBL9533660 | 0.85 | HDAC8 (0.36) | TSHRALDH1A1LMNAHDAC8HTR2C | |
| SCHEMBL9533982 | 0.82 | TSHR (0.52) | TSHRALDH1A1LMNAHTTPOLB | |
| SCHEMBL9533307 | 0.82 | TSHR (0.52) | TSHRALDH1A1LMNAHTTPOLB | |
| SCHEMBL9532198 | 0.80 | TSHR (0.53) | TSHRALDH1A1LMNAHTTMAPK1 | |
| SCHEMBL11851033 | 0.79 | TSHR (0.49) | TSHRSMARCA2LMNAHTR2CNR1I2 | |
| SCHEMBL11855311 | 0.76 | TSHR (0.58) | TSHRSMARCA2ALDH1A1LMNAHTR2C | |
| SCHEMBL11842418 | 0.76 | LMNA (0.44) | TSHRSMARCA2LMNAHDAC8HTR2C | |
| SCHEMBL11850497 | 0.74 | LMNA (0.45) | TSHRSMARCA2LMNAHTTHDAC8 | |
| SCHEMBL11850001 | 0.73 | TSHR (0.74) | TSHRSMARCA2ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0360261-B1 | Substituted Imidazol[2,1-b] quinazolin-5(3H)-ones and related tricyclic compounds | MERRELL DOW PHARMA (US) | 1993-10-27 | — | — | EP | disclosed |
| EP-0360261-A1 | Substituted Imidazol[2,1-b] quinazolin-5(3H)-ones and related tricyclic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-28 | — | — | EP | disclosed |
| US-4871732-A | Substituted imidazo(2,1-b)quinazolin-5(3H)-ones and related tricyclic compounds and use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-03 | — | — | US | disclosed |