Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534710 | 0.88 | KDM4E (0.38) | HDAC8TP53LMNATSHRALDH1A1 | |
| SCHEMBL9537414 | 0.85 | TSHR (0.46) | HDAC8LMNATSHRALDH1A1ACHE | |
| SCHEMBL9533307 | 0.82 | TSHR (0.52) | TP53LMNATSHRMEN1KMT2A | |
| SCHEMBL9533982 | 0.82 | TSHR (0.52) | TP53LMNATSHRMEN1KMT2A | |
| SCHEMBL9532198 | 0.80 | TSHR (0.53) | TP53LMNATSHRMEN1KMT2A | |
| SCHEMBL9534186 | 0.73 | TSHR (0.44) | HDAC8TP53LMNATSHRMEN1 | |
| SCHEMBL9533704 | 0.73 | TSHR (0.51) | LMNATSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL9533440 | 0.71 | TSHR (0.39) | TP53LMNATSHRMEN1KMT2A | |
| SCHEMBL9532975 | 0.71 | TSHR (0.39) | TP53LMNATSHRMEN1KMT2A | |
| SCHEMBL15517607 | 0.70 | KMT2A (0.44) | TP53TSHRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0360261-B1 | Substituted Imidazol[2,1-b] quinazolin-5(3H)-ones and related tricyclic compounds | MERRELL DOW PHARMA (US) | 1993-10-27 | — | — | EP | disclosed |
| EP-0360261-A1 | Substituted Imidazol[2,1-b] quinazolin-5(3H)-ones and related tricyclic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-28 | — | — | EP | disclosed |
| US-4871732-A | Substituted imidazo(2,1-b)quinazolin-5(3H)-ones and related tricyclic compounds and use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-03 | — | — | US | disclosed |