Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.43 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985049 | 0.84 | KCNH2 (0.65) | KCNH2NR4A2SSTR5 | |
| SCHEMBL6991613 | 0.82 | KCNH2 (0.59) | KCNH2NR4A2KDM4EALDH1A1 | |
| SCHEMBL7981124 | 0.81 | KCNH2 (0.61) | KCNH2NR4A2POLBCYP1A2CYP3A4 | |
| SCHEMBL6992893 | 0.81 | KCNH2 (0.59) | KCNH2NR4A2KDM4EALDH1A1LMNA | |
| SCHEMBL7980989 | 0.81 | KCNH2 (0.58) | KCNH2NR4A2KDM4EALDH1A1LMNA | |
| SCHEMBL5537223 | 0.81 | KCNH2 (0.58) | KCNH2NR4A2LMNACYP1A2CYP3A4 | |
| SCHEMBL9535562 | 0.81 | KCNH2 (0.60) | KCNH2NR4A2ALDH1A1HPGDLMNA | |
| SCHEMBL13319057 | 0.81 | KCNH2 (0.63) | KCNH2NR4A2HIF1AALDH1A1HPGD | |
| SCHEMBL6991720 | 0.80 | KCNH2 (0.57) | KCNH2NR4A2POLBKDM4EHIF1A | |
| Hydrochloric Acid SCHEMBL5009615 | 0.80 | KCNH2 (0.58) | KCNH2NR4A2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282133-B1 | 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-28 | — | — | EP | disclosed |
| EP-0282133-A2 | 1-alkyl substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-09-14 | — | — | EP | disclosed |