Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 2/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534791 | 0.96 | KDM4E (0.42) | KDM4ECHRNB4CHRNA3ITGB2ICAM1 | |
| SCHEMBL461998 | 0.91 | ITGB2 (0.50) | KDM4ECHRNB4CHRNA3ITGB2ICAM1 | |
| SCHEMBL11188752 | 0.86 | SMN1; SMN2 (0.57) | KDM4EITGB2ICAM1ITGALMTNR1A | |
| SCHEMBL11194835 | 0.86 | SMN1; SMN2 (0.57) | KDM4EITGB2ICAM1ITGALMTNR1A | |
| SCHEMBL10018030 | 0.79 | ITGB2 (0.41) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL118556 | 0.78 | ABCG2 (0.50) | KDM4ECHRNB4CHRNA3LMNAMAOB | |
| SCHEMBL13516866 | 0.77 | ITGB2 (0.42) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL28507933 | 0.76 | BCL2L1 (0.52) | — | |
| SCHEMBL5673196 | 0.73 | BCL2L1 (0.48) | ITGB2ICAM1ITGALMTNR1ALMNA | |
| SCHEMBL31598947 | 0.73 | BCL2L1 (0.48) | ITGB2ICAM1ITGALMTNR1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254595-A | Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them | ELF SANOFI (FR) | 1993-10-19 | — | — | US | disclosed |
| EP-0375560-B1 | ARYLOXYPROPANOLAMINOTETRALINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ELF SANOFI (FR) | 1993-05-12 | — | — | EP | disclosed |
| EP-0375560-A1 | Aryloxypropanolaminotetralines, process for their preparation and pharmaceutical compositions containing same | ELF SANOFI (FR) | 1990-06-27 | — | — | EP | disclosed |