Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 5/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537584 | 0.91 | MEN1 (0.56) | MEN1KMT2ALMNAHTTKDM4E | |
| SCHEMBL9537554 | 0.90 | HRH1 (0.63) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL9537631 | 0.89 | HRH1 (0.54) | MEN1KMT2ATP53LMNAMAPT | |
| Hydrochloric Acid SCHEMBL9539517 | 0.89 | HRH1 (0.62) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL9535902 | 0.88 | MEN1 (0.63) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL9540054 | 0.88 | TP53 (0.59) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL9536524 | 0.85 | MEN1 (0.47) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL9540561 | 0.84 | MEN1 (0.48) | MEN1KMT2ATP53LMNAMAPT | |
| Fumaric Acid SCHEMBL10817907 | 0.82 | MEN1 (0.53) | MEN1KMT2ATP53LMNAMAPT | |
| SCHEMBL9537111 | 0.81 | KCNH2 (0.63) | MEN1KMT2ATP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |