Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535164 | 0.91 | MEN1 (0.54) | MEN1KMT2ACYP2D6CYP1A2CYP2C9 | |
| SCHEMBL9537554 | 0.91 | HRH1 (0.63) | MEN1KMT2ACYP2D6CYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL9539517 | 0.91 | HRH1 (0.62) | MEN1KMT2ACYP2D6CYP1A2CYP2C19 | |
| SCHEMBL5626341 | 0.89 | MEN1 (0.66) | MEN1KMT2ACYP2D6CYP1A2CYP2C9 | |
| SCHEMBL9537631 | 0.89 | HRH1 (0.54) | MEN1KMT2ACYP2D6CYP1A2CYP2C19 | |
| SCHEMBL9538432 | 0.89 | PRMT3 (0.59) | MEN1KMT2ACYP2D6CYP1A2CYP2C9 | |
| SCHEMBL9537470 | 0.84 | KDM4E (0.50) | CYP2D6ALDH1A1KDM4ETSHRPOLB | |
| SCHEMBL9539993 | 0.84 | MEN1 (0.48) | MEN1KMT2ACYP2D6CYP1A2CYP2C9 | |
| SCHEMBL9535902 | 0.83 | MEN1 (0.63) | MEN1KMT2ACYP2D6CYP1A2CYP2C9 | |
| SCHEMBL9536543 | 0.83 | SSTR5 (0.66) | MEN1KMT2ACYP2D6CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |