Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 8/20 | 0.60 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534320 | 0.86 | MEN1 (0.60) | AKR1B1AKR1A1MAPTMEN1KMT2A | |
| SCHEMBL9537117 | 0.85 | AKR1B1 (0.60) | AKR1B1AKR1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9535268 | 0.84 | AKR1B1 (0.59) | AKR1B1AKR1A1MAPTMEN1KMT2A | |
| SCHEMBL9535570 | 0.84 | AKR1B1 (0.66) | AKR1B1AKR1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL10487918 | 0.82 | AKR1B1 (0.76) | AKR1B1AKR1A1MAPTMEN1KMT2A | |
| SCHEMBL9534750 | 0.81 | AKR1B1 (0.55) | AKR1B1AKR1A1MAPTMEN1KMT2A | |
| SCHEMBL10487878 | 0.79 | AKR1B1 (0.86) | AKR1B1AKR1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL10488000 | 0.78 | AKR1B1 (0.67) | AKR1B1AKR1A1MAPTMEN1KMT2A | |
| SCHEMBL9056716 | 0.77 | AKR1B1 (0.78) | AKR1B1AKR1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9319101 | 0.77 | AKR1B1 (0.81) | AKR1B1AKR1A1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0568540-A1 | 2,4-DIOXO-PYRIDO 2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1993-11-10 | — | — | EP | claimed |
| WO-1992012979-A1 | 2,4-DIOXO-PYRIDO [2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1992-08-06 | — | — | WO | claimed |
| EP-0568540-A1 | 2,4-DIOXO-PYRIDO 2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1993-11-10 | — | — | EP | disclosed |
| WO-1992012979-A1 | 2,4-DIOXO-PYRIDO [2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1992-08-06 | — | — | WO | disclosed |