Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535225 | 0.86 | AKR1B1 (0.60) | MEN1KMT2AAKR1B1MAPTAKR1A1 | |
| SCHEMBL10487846 | 0.84 | AKR1B1 (0.57) | MEN1KMT2AAKR1B1MAPTAKR1A1 | |
| SCHEMBL10487913 | 0.82 | AKR1B1 (0.64) | MEN1KMT2AAKR1B1MAPTAKR1A1 | |
| SCHEMBL10487889 | 0.81 | AKR1B1 (0.52) | MEN1KMT2AAKR1B1MAPTAKR1A1 | |
| SCHEMBL10487995 | 0.80 | AKR1A1 (0.47) | MEN1KMT2AAKR1B1MAPTAKR1A1 | |
| SCHEMBL9046143 | 0.80 | AKR1A1 (0.59) | MEN1KMT2AAKR1B1MAPTAKR1A1 | |
| SCHEMBL10487925 | 0.79 | AKR1B1 (0.61) | MEN1KMT2AAKR1B1MAPTAKR1A1 | |
| SCHEMBL9048154 | 0.79 | ALDH1A1 (0.49) | MEN1KMT2AAKR1B1MAPTAKR1A1 | |
| SCHEMBL10487808 | 0.79 | AKR1B1 (0.60) | MEN1KMT2AAKR1B1MAPTAKR1A1 | |
| SCHEMBL10487923 | 0.78 | AKR1B1 (0.59) | MEN1KMT2AAKR1B1MAPTAKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0568540-A1 | 2,4-DIOXO-PYRIDO 2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1993-11-10 | — | — | EP | disclosed |
| WO-1992012979-A1 | 2,4-DIOXO-PYRIDO [2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1992-08-06 | — | — | WO | disclosed |