Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 2/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57392 | 0.90 | CES1 (0.55) | CALM1CES2CES1AKR1B1KMT2A | |
| SCHEMBL28774551 | 0.87 | CES1 (0.52) | CALM1CES2CES1AKR1B1KMT2A | |
| Ammonia Solution, Strong SCHEMBL28157017 | 0.87 | CES1 (0.52) | CALM1CES2CES1AKR1B1KMT2A | |
| SCHEMBL8781892 | 0.81 | LMNA (0.61) | LMNAKMT2AMEN1 | |
| Diphenylmethane SCHEMBL11211579 | 0.79 | CALM1 (0.80) | LMNACALM1LTA4HIDH1PLA2G10 | |
| Diphenylmethane SCHEMBL10394702 | 0.79 | CALM1 (0.92) | LMNACALM1LTA4HIDH1PLA2G10 | |
| SCHEMBL8094422 | 0.79 | CALM1 (0.92) | LMNACALM1LTA4HIDH1PLA2G10 | |
| SCHEMBL972712 | 0.79 | CALM1 (0.92) | LMNACALM1LTA4HIDH1PLA2G10 | |
| SCHEMBL5696415 | 0.76 | AKR1B1 (0.81) | LMNACALM1PLA2G10PLA2G2ACES2 | |
| Hydrochloric Acid SCHEMBL27978245 | 0.76 | CALM1 (0.86) | LMNACALM1LTA4HIDH1PLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532693-A1 | 1,4-DIAMINO-2,3-DIHYDROXYBUTANES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-24 | — | — | EP | disclosed |