Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.60 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.60 |
| ▸ | EDNRA | P25101 | 1/20 | 0.60 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | TOP2A | P11388 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.43 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2094951 | 0.91 | LMNA (0.48) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL2097125 | 0.91 | LMNA (0.48) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL11278689 | 0.87 | LMNA (0.48) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL2092612 | 0.86 | LMNA (0.44) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL2092155 | 0.86 | LMNA (0.44) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL2092702 | 0.85 | PIM3 (0.57) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL10824682 | 0.85 | LMNA (0.46) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL2093744 | 0.84 | PIM3 (0.45) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL2092205 | 0.83 | PIM3 (0.55) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL2093030 | 0.83 | PIM3 (0.54) | LMNACYP2C9ATP6V1B2TBXA2REDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153580-B2 | NAPHTHYRIDINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4962112-A | 7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline compounds | ABBOTT LABORATORIES (US) | 1990-10-09 | — | — | US | disclosed |
| US-4880814-A | 7-cycloalkyl naphthyridines | ABBOTT LABORATORIES (US) | 1989-11-14 | — | — | US | disclosed |
| EP-0302371-A2 | 7-(2-Methyl-4-aminopyrrolidinyl)naphthyridine and quinoline compounds | ABBOTT LABORATORIES (US) | 1989-02-08 | — | — | EP | disclosed |
| EP-0153580-B1 | NAPHTHYRIDINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-01-25 | — | — | EP | disclosed |
| US-4616019-A | ANTIBIOTIC | ABBOTT LABORATORIES (US) | 1986-10-07 | — | — | US | disclosed |
| EP-0153580-A1 | Naphthyridine antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-09-04 | — | — | EP | disclosed |