Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9535594 | 1.00 | MAPT (0.42) | MAPTMAPK14OPRM1OPRD1OPRK1 | |
| SCHEMBL10697050 | 0.86 | MAPT (0.44) | MAPTOPRM1OPRD1OPRK1NPSR1 | |
| Oxalic Acid SCHEMBL9536954 | 0.85 | SLC6A9 (0.41) | MAPTOPRM1OPRD1OPRK1NPSR1 | |
| Oxalic Acid SCHEMBL9536963 | 0.85 | SLC6A9 (0.41) | MAPTOPRM1OPRD1OPRK1NPSR1 | |
| SCHEMBL9535868 | 0.83 | SLC6A9 (0.44) | MAPTNOS2 | |
| Oxalic Acid SCHEMBL9539814 | 0.83 | HRH1 (0.47) | MAPTOPRM1OPRD1OPRK1TP53 | |
| Oxalic Acid SCHEMBL9539822 | 0.83 | HRH1 (0.47) | MAPTOPRM1OPRD1OPRK1TP53 | |
| Hydrochloric Acid SCHEMBL10384124 | 0.82 | SLC6A9 (0.44) | MAPTNOS2 | |
| Fumaric Acid SCHEMBL10383182 | 0.82 | MAPT (0.40) | MAPTMAPK14OPRM1OPRD1OPRK1 | |
| Oxalic Acid SCHEMBL10383155 | 0.81 | SLC6A9 (0.41) | MAPTOPRM1OPRD1OPRK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282133-B1 | 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-28 | — | — | EP | disclosed |
| US-4943580-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0282133-A2 | 1-alkyl substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-09-14 | — | — | EP | disclosed |