Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 15/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535833 | 0.77 | SMN1; SMN2 (0.37) | TYMPALDH1A1NPC1KDM4EGAA | |
| SCHEMBL10786702 | 0.77 | SMN1; SMN2 (0.37) | TYMPALDH1A1NPC1KDM4EGAA | |
| SCHEMBL19348252 | 0.67 | CRBN (0.43) | ATMALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4889955 | 0.66 | TYMP (0.47) | TYMPATMALDH1A1KDM4EMEN1 | |
| SCHEMBL6027678 | 0.65 | TYMP (0.46) | TYMPATMALDH1A1KDM4EGAA | |
| SCHEMBL8768819 | 0.62 | TYMP (0.44) | TYMPATMALDH1A1KDM4EMEN1 | |
| SCHEMBL10565144 | 0.61 | TYMP (0.40) | TYMPATMALDH1A1KDM4EGAA | |
| SCHEMBL18072360 | 0.60 | HSD17B10 (0.53) | TYMPATMALDH1A1KDM4EMEN1 | |
| SCHEMBL15469004 | 0.60 | POLB (0.43) | TYMPATMALDH1A1KDM4EGAA | |
| SCHEMBL4960409 | 0.60 | POLB (0.46) | TYMPATMALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168813-B1 | Sparsomycin derivatives | MERRELL DOW PHARMA (US) | 1993-11-10 | — | — | EP | disclosed |
| EP-0108455-B1 | SPARSOMYCIN (SC-RS) DERIVATIVE; PHARMACEUTICAL COMPOSITION HAVING ANTI-TUMOR ACTIVITY | Stichting Katholieke Universiteit (NL) | 1987-04-22 | — | — | EP | disclosed |
| US-4581360-A | Sparsomycin (Sc -Rs) derivative; pharmaceutical composition having anti-tumor activity | STICHTING KATHOLIEKE UNIVERSITEIT (NL) | 1986-04-08 | — | — | US | disclosed |
| EP-0168813-A1 | Sparsomycin derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-01-22 | — | — | EP | disclosed |
| EP-0108455-A1 | Sparsomycin (Sc-Rs) derivative; pharmaceutical composition having anti-tumor activity | Stichting Katholieke Universiteit (NL) | 1984-05-16 | — | — | EP | disclosed |