Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 5/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30423980 | 0.83 | ALDH1A1 (0.47) | TYMPGRIN2DGRIN3BGRIA1GRIA2 | |
| SCHEMBL8768819 | 0.79 | TYMP (0.44) | TYMPKDM4EALDH1A1CYP3A4HPGD | |
| SCHEMBL7962149 | 0.79 | ALDH1A1 (0.58) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL4960409 | 0.77 | POLB (0.46) | TYMPLMNAKDM4EALDH1A1CYP3A4 | |
| SCHEMBL18072360 | 0.76 | HSD17B10 (0.53) | TYMPLMNAKDM4EALDH1A1MAPT | |
| SCHEMBL4618373 | 0.75 | KDM4E (0.46) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL11503765 | 0.75 | LMNA (0.50) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL4469664 | 0.74 | KDM4E (0.45) | TYMPLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL4480638 | 0.74 | HPGD (0.66) | TYMPLMNAKDM4EALDH1A1CYP3A4 | |
| SCHEMBL29776965 | 0.73 | B3GNT2 (0.43) | TYMPGRIN1GRIN2BLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214589-A1 | Thrombin Inhibiting 2,4-Dioxo-3,4-Dihydropyrimidine Derivatives | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | US | disclosed |
| EP-0792283-A1 | SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH | CHIRON CORPORATION (US) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015143-A1 | SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH | CHIRON CORPORATION (US) | 1996-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214589-A1 | Thrombin Inhibiting 2,4-Dioxo-3,4-Dihydropyrimidine Derivatives | F2, PLAT, F2R | TYMP 114/4885GRIN2D 2709/4885GRIN3B 2670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.