Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 14/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458606 | 0.85 | ALOX5 (0.53) | ALOX5PTGESPTGS1MEN1KMT2A | |
| SCHEMBL9458503 | 0.74 | ALOX5 (0.70) | ALOX5PTGESPTGS1PDE3BPDE3A | |
| SCHEMBL6483250 | 0.74 | PTGES (0.58) | ALOX5PTGESPTGS1PDE3BPDE3A | |
| SCHEMBL6485138 | 0.74 | PTGES (0.58) | ALOX5PTGESPTGS1PDE3BPDE3A | |
| SCHEMBL7003381 | 0.72 | PTGES (0.56) | ALOX5PTGESPTGS1PDE3BPDE3A | |
| SCHEMBL7003600 | 0.72 | PTGES (0.56) | ALOX5PTGESPTGS1PDE3BPDE3A | |
| SCHEMBL9458734 | 0.69 | PTGES (0.65) | ALOX5PTGESPTGS1 | |
| Ethyl Acetate SCHEMBL7738813 | 0.69 | PTGES (0.52) | ALOX5PTGESPTGS1PDE3BPDE3A | |
| SCHEMBL6475789 | 0.68 | KMT2A (0.56) | PDE3BPDE3AMEN1KMT2A | |
| SCHEMBL6477477 | 0.68 | PDE3B (0.51) | ALOX5PDE3BPDE3AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397175-B1 | Substituted pyrrolizine compounds and theit use as pharmaceuticals | DANNHARDT GERD PROF DR (DE) | 1993-12-08 | — | — | EP | disclosed |
| EP-0397175-A1 | Substituted pyrrolizine compounds and theit use as pharmaceuticals | Dannhardt, Gerd, Prof.Dr. (DE) | 1990-11-14 | — | — | EP | disclosed |