Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536870 | 0.86 | F10 (0.41) | NOTUMMAPTTHRBMAPK1CYP11B1 | |
| SCHEMBL9539211 | 0.85 | ADRB2 (0.46) | NOTUMMAPTTSHRMAPK1HTT | |
| SCHEMBL9540984 | 0.84 | CYP11B1 (0.44) | MAPTTHRBTSHRMAPK1CYP11B1 | |
| SCHEMBL9540553 | 0.84 | MAPT (0.47) | NOTUMMAPTTSHRCYP11B1CYP11B2 | |
| SCHEMBL11147651 | 0.84 | NOTUM (0.66) | NOTUMMAPTPOLB | |
| SCHEMBL11136938 | 0.83 | NOTUM (0.47) | NOTUMTSHRCYP11B1CYP11B2XIAP | |
| SCHEMBL9537029 | 0.83 | CYP11B1 (0.43) | MAPTTHRBTSHRHTTCYP11B1 | |
| SCHEMBL9538397 | 0.83 | NOTUM (0.42) | NOTUMMAPTTHRBPOLBDRD2 | |
| SCHEMBL9537808 | 0.83 | TP53 (0.40) | MAPTTSHRCYP11B1CYP11B2POLB | |
| SCHEMBL9803972 | 0.83 | NOTUM (0.44) | NOTUMMAPTTHRBTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180352-B1 | BENZENE-FUSED HETEROCYCLIC COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-26 | — | — | EP | disclosed |
| US-4767780-A | SUBSTITUTED 1,4-DIHYDRO-(1)-BENZOPYRANO(4,3-C)PYRAZOLES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| US-4675324-A | Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric, diuretic and anti-hypertensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-23 | — | — | US | disclosed |
| EP-0180352-A2 | Benzene-fused heterocyclic compound | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |
| US-4421919-A | ANTIEDEMIC, DIURETIC, HYPOTENSIVE | HODOGAYA CHEMICAL CO., LTD. (JP) | 1983-12-20 | — | — | US | disclosed |