Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | NAAA | Q02083 | 5/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11144093 | 0.85 | ADRB2 (0.44) | ADRB2ADRB1ADRB3DRD2NAAA | |
| SCHEMBL11144200 | 0.85 | ADRB2 (0.44) | ADRB2ADRB1ADRB3DRD2NAAA | |
| SCHEMBL11144199 | 0.85 | ADRB2 (0.44) | ADRB2ADRB1ADRB3DRD2NAAA | |
| SCHEMBL11144089 | 0.85 | ADRB2 (0.44) | ADRB2ADRB1ADRB3DRD2NAAA | |
| SCHEMBL9535907 | 0.85 | NOTUM (0.47) | DRD2NOTUMMAPTTSHRMAPK1 | |
| SCHEMBL11141056 | 0.84 | ADRB2 (0.42) | ADRB2ADRB1ADRB3DRD2NAAA | |
| SCHEMBL11141059 | 0.84 | ADRB2 (0.42) | ADRB2ADRB1ADRB3DRD2NAAA | |
| SCHEMBL9538397 | 0.82 | NOTUM (0.42) | DRD2NPC1NOTUMLMNAMAPT | |
| SCHEMBL11144619 | 0.80 | NOTUM (0.40) | ADRB2ADRB1ADRB3DRD2NPC1 | |
| SCHEMBL11144616 | 0.80 | NOTUM (0.40) | ADRB2ADRB1ADRB3DRD2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180352-B1 | BENZENE-FUSED HETEROCYCLIC COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-26 | — | — | EP | disclosed |
| US-4767780-A | SUBSTITUTED 1,4-DIHYDRO-(1)-BENZOPYRANO(4,3-C)PYRAZOLES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| US-4675324-A | Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric, diuretic and anti-hypertensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-23 | — | — | US | disclosed |
| EP-0180352-A2 | Benzene-fused heterocyclic compound | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |