Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 11/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10382652 | 0.91 | MAPT (0.55) | MAPTKMT2AMEN1LMNATDP1 | |
| SCHEMBL9536843 | 0.88 | MAPT (0.48) | MAPTKMT2AMEN1LMNATDP1 | |
| SCHEMBL10381857 | 0.85 | MAPT (0.50) | MAPTKMT2AMEN1LMNATDP1 | |
| SCHEMBL9533962 | 0.84 | MAOB (0.62) | MAPTKMT2AMEN1LMNATDP1 | |
| SCHEMBL9536646 | 0.81 | CD274 (0.50) | MAPTKMT2AMEN1LMNATDP1 | |
| SCHEMBL10381181 | 0.80 | MAOB (0.58) | MAPTKMT2AMEN1LMNATDP1 | |
| SCHEMBL10381192 | 0.79 | MAOB (0.59) | MAPTKMT2AMEN1LMNATDP1 | |
| SCHEMBL5457017 | 0.78 | CD274 (0.56) | MAPTKMT2AMEN1LMNATDP1 | |
| SCHEMBL3261412 | 0.78 | MAPT (0.66) | MAPTKMT2AMEN1LMNATDP1 | |
| SCHEMBL10382658 | 0.78 | MAOB (0.65) | MAPTKMT2AMEN1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539372-A1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1991011448-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1991-08-08 | — | — | WO | disclosed |
| WO-1990001481-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1990-02-22 | — | — | WO | disclosed |
| EP-0354693-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1990-02-14 | — | — | EP | disclosed |