Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 11/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 9/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536506 | 0.86 | CD274 (0.54) | CD274PDCD1BRD4KDM4EALDH1A1 | |
| SCHEMBL9535942 | 0.81 | MAPT (0.54) | CD274PDCD1MAPTKMT2AMEN1 | |
| SCHEMBL24190672 | 0.74 | CD274 (0.45) | CD274PDCD1MAPTKMT2AMEN1 | |
| SCHEMBL10382652 | 0.73 | MAPT (0.55) | CD274PDCD1MAPTKMT2AMEN1 | |
| SCHEMBL9533843 | 0.71 | MAOB (0.49) | CD274PDCD1BRD4KMT2AMEN1 | |
| SCHEMBL10381857 | 0.71 | MAPT (0.50) | CD274PDCD1MAPTKMT2AMEN1 | |
| SCHEMBL9536843 | 0.71 | MAPT (0.48) | CD274PDCD1MAPTKMT2AMEN1 | |
| SCHEMBL9534350 | 0.68 | MAPT (0.59) | CD274PDCD1MAPTLMNAKDM4E | |
| SCHEMBL9534473 | 0.68 | CD274 (0.59) | CD274PDCD1MAPTKMT2AMEN1 | |
| SCHEMBL22908621 | 0.67 | CD274 (1.00) | CD274PDCD1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539372-A1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1991011448-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1991-08-08 | — | — | WO | disclosed |