SCHEMBL9533962

SCHEMBL9533962

O=C1CC(c2ccccc2O)=NN1c1ccc(Cl)cc1

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.62
MAPT P10636 6/20 0.52
MEN1 O00255 6/20 0.52
KMT2A Q03164 6/20 0.52
TDP1 Q9NUW8 3/20 0.52
LMNA P02545 2/20 0.52
ALDH1A1 P00352 1/20 0.52
HTT P42858 1/20 0.52
PRKCZ Q05513 1/20 0.49
PDCD1 Q15116 2/20 0.47
CD274 Q9NZQ7 2/20 0.47
KDM4E B2RXH2 2/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
GAA P10253 3/20 0.45
USP2 O75604 1/20 0.45
NPSR1 Q6W5P4 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
RECQL P46063 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10382659 0.88 MAOB (0.64) MAOBMAPTMEN1KMT2ATDP1
SCHEMBL9536771 0.88 MAOB (0.61) MAOBMAPTMEN1KMT2APRKCZ
SCHEMBL10381181 0.87 MAOB (0.58) MAOBMAPTMEN1KMT2ATDP1
SCHEMBL9536658 0.87 MAOB (0.64) MAOBMAPTMEN1KMT2ATDP1
SCHEMBL9534735 0.86 MAOB (0.63) MAOBMAPTKMT2ATDP1PDCD1
SCHEMBL9532937 0.86 MAOB (0.62) MAOBMAPTMEN1KMT2ATDP1
SCHEMBL10381192 0.86 MAOB (0.59) MAOBMAPTMEN1KMT2ATDP1
SCHEMBL9534068 0.86 MAOB (0.62) MAOBMAPTMEN1KMT2ATDP1
SCHEMBL10381309 0.86 MAOB (0.60) MAOBMAPTMEN1KMT2ATDP1
SCHEMBL9535942 0.84 MAPT (0.54) MAOBMAPTMEN1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0539372-A1 THERAPEUTIC AGENTS The Boots Company PLC (GB) 1993-05-05 EP disclosed
WO-1991011448-A1 THERAPEUTIC AGENTS THE BOOTS COMPANY PLC (GB) 1991-08-08 WO disclosed
WO-1990001481-A1 THERAPEUTIC AGENTS THE BOOTS COMPANY PLC (GB) 1990-02-22 WO disclosed
EP-0354693-A1 Therapeutic agents The Boots Company PLC (GB) 1990-02-14 EP disclosed