Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6211205 | 0.93 | LMNA (0.50) | CAPN1PIM1EPHA2FLT4GSK3B | |
| SCHEMBL7012691 | 0.92 | EPHA2 (0.45) | CAPN1PIM1EPHA2FLT4GSK3B | |
| SCHEMBL27810661 | 0.91 | PIM1 (0.43) | CAPN1PIM1EPHA2FLT4GSK3B | |
| SCHEMBL7008218 | 0.86 | PIM1 (0.46) | PIM1EPHA2FLT4GSK3BRARB | |
| SCHEMBL9056315 | 0.85 | CSF1R (0.42) | CAPN1PIM1EPHA2FLT4GSK3B | |
| SCHEMBL9058125 | 0.84 | PIM1 (0.39) | CAPN1PIM1EPHA2FLT4GSK3B | |
| SCHEMBL19971451 | 0.83 | EPHA2 (0.44) | PIM1EPHA2FLT4GSK3BRARB | |
| SCHEMBL27274437 | 0.83 | LMNA (0.47) | CAPN1PIM1EPHA2FLT4GSK3B | |
| SCHEMBL27271653 | 0.83 | LMNA (0.52) | CAPN1PIM1EPHA2FLT4GSK3B | |
| SCHEMBL7010440 | 0.83 | TOP1 (0.45) | CAPN1PIM1EPHA2FLT4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153580-B2 | NAPHTHYRIDINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0153580-B1 | NAPHTHYRIDINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-01-25 | — | — | EP | disclosed |
| EP-0153580-A1 | Naphthyridine antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-09-04 | — | — | EP | disclosed |