Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535955 | 0.92 | CAPN1 (0.49) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL6211205 | 0.92 | LMNA (0.50) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL27810661 | 0.90 | PIM1 (0.43) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL27789088 | 0.87 | KDM4E (0.53) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL19971451 | 0.87 | EPHA2 (0.44) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL8126948 | 0.87 | PDE4A (0.37) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL27810663 | 0.86 | EPHA2 (0.44) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL7008218 | 0.85 | PIM1 (0.46) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL9536041 | 0.85 | NPC1 (0.46) | KDM4EHPGDALDH1A1KMT2APIM1 | |
| SCHEMBL9056315 | 0.84 | CSF1R (0.42) | EPHA2FLT4GSK3BRARBTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0614664-B2 | Quinolonecarboxylic acid derivatives, their preparation and their use as cell adhesion inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-01-08 | — | — | EP | disclosed |
| CN-1063747-C | Quinolone- and naphthyridonecarboxylic acid derivatives | BAYER AG (DE) | 2001-03-28 | — | — | CN | disclosed |
| EP-0704443-B1 | Quinolone and naphthyridone carboxylic acid derivatives | BAYER AG (DE) | 2000-12-27 | — | — | EP | disclosed |
| EP-0401623-B1 | Process for the preparation of 7-(3-amino- and 3-aminomethyl-1-pyrrolidinyl)-3-quinolinonecarboxylic and -naphthyridinonecarboxylic acids | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| US-6018054-A | INTERMEDIATE COMPOUNDS FOR PREPARING NOVEL QUINOLONE AND NAPHTHYRIDONE DERIVATIVES WHICH ARE SUBSTITUTED IN THE 7-POSITION BY A PARTIALLY HYDROGENATED ISOINDOLINYL RING, USE AS ANTIBACTERIAL AGENTS AND AS FEED ADDITIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |
| EP-0705828-B1 | Quinolone- and naphthyridone carboxylic acid derivatives as antibacterial agents | BAYER AG (DE) | 1999-12-01 | — | — | EP | disclosed |
| US-5990122-A | SUBSTITUTED IN THE 7-POSITION BY A TRICYCLIC AMINE RADICAL; REDUCED GENOTOXIC PROPERTIES AND INCREASED ANTIBACTERIAL ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 1999-11-23 | — | — | US | disclosed |
| US-5986105-A | ENANTIOMORPHS AS BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-11-16 | — | — | US | disclosed |
| CN-1044118-C | 7-isoindolinyl-quinolone derivatives and process for their preparation | BAYER AG (DE) | 1999-07-14 | — | — | CN | disclosed |
| US-5889009-A | ADMINISTERING 1,7-DISUBSTITUTED-4-OX-3-(QUINOLINECARBOXYLIC ACID OR NAPHTHYRIDINECARBOXYLIC ACID) | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-30 | — | — | US | disclosed |
| US-4990517-A | 7-(1-pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives as antibacterial agents and feed additives | BAYER AKTIENGESELLSCHAFT (DE) | 1991-02-05 | — | — | US | disclosed |
| EP-0401623-A1 | Process for the preparation of 7-(3-amino- and 3-aminomethyl-1-pyrrolidinyl)-3-quinolinonecarboxylic and -naphthyridinonecarboxylic acids | BAYER AG (DE) | 1990-12-12 | — | — | EP | disclosed |
| CN-1039589-A | 7- (1-pyrrolidinyl) -3-quinolone-and 1, 5-naphthyridonecarboxylic acid derivatives and process for preparing same | BAYER AG (DE) | 1990-02-14 | — | — | CN | disclosed |
| EP-0350733-A2 | 7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic-acid derivatives, method for their preparation and for substituted mono- and bi-cyclic pyrrolidine intermediates, and their antibacterial and feed additive compositions | BAYER AG (DE) | 1990-01-17 | — | — | EP | disclosed |
| EP-0326916-A2 | Quinolone- and naphthyridone-carboxylic acid derivatives, method for their preparation and antibacterial agents and food additives containing them | BAYER AG (DE) | 1989-08-09 | — | — | EP | disclosed |
| EP-0153580-B1 | NAPHTHYRIDINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-01-25 | — | — | EP | disclosed |
| CN-87100354-A | Derivatives of 7- (azabicycloalkyl) -quinolone-and 7- (azabicycloalkyl) -naphthyridonecarboxylic acids | — | 1987-09-02 | — | — | CN | disclosed |
| EP-0230274-A2 | Derivatives of 7-(azabicycloalkyl)-quinoloncarboxylic acid and -naphthyridoncarboxylic acid | BAYER AG (DE) | 1987-07-29 | — | — | EP | disclosed |
| US-4616019-A | ANTIBIOTIC | ABBOTT LABORATORIES (US) | 1986-10-07 | — | — | US | disclosed |
| EP-0153580-A1 | Naphthyridine antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-09-04 | — | — | EP | disclosed |