Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | THPO | P40225 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 9/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9586636 | 0.99 | NPY1R (0.64) | NPY1RTP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9537137 | 0.91 | ADRB3 (0.56) | NPY1RTP53CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL9587385 | 0.90 | ADRB3 (0.55) | NPY1RTP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9536903 | 0.88 | NPY1R (0.84) | NPY1RTP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9588852 | 0.84 | CYP3A4 (0.62) | NPY1RTP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9534987 | 0.84 | TP53 (0.57) | NPY1RTP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22279238 | 0.82 | ADRB3 (0.70) | ADRB3ADRB1 | |
| SCHEMBL9538527 | 0.81 | TP53 (0.72) | NPY1RTP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22279183 | 0.81 | ADRB3 (0.51) | NPY1RADRB3ADRB1 | |
| SCHEMBL9538433 | 0.80 | TP53 (0.60) | NPY1RTP53CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375560-B1 | ARYLOXYPROPANOLAMINOTETRALINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ELF SANOFI (FR) | 1993-05-12 | — | — | EP | disclosed |
| EP-0375560-A1 | Aryloxypropanolaminotetralines, process for their preparation and pharmaceutical compositions containing same | ELF SANOFI (FR) | 1990-06-27 | — | — | EP | disclosed |